Trustworthy and quality-assured quantitative magnetic resonance imaging

To embed self-evaluations of pixel-wise uncertainty into quantitative MRI reconstructions

Start date: June 1st, 2025
Duration: 36 months
Coordinator: Dr. Luca Zilberti, INRiM

In his Metamorphoses (also known as The Golden Ass) the Latin writer Apuleius provides an allegory of a person’s path towards maturity. In this project, we develop the metrological framework required to bring quantitative MRI towards maturity. Specifically, we aim to embed self-evaluations of pixel-wise uncertainty into quantitative MRI reconstructions.

Unleash the full potential of qMRI

Metrological framework to enable pixel-wise uncertainty

Short-term intra-subject measurements to validate the metrological framework

Publication of suitable benchmarks to foster objective comparison of different qMRI algorithms

Inter-subject, inter-protocol and longitudinal intra-subject observations to identify target uncertainties and optimise qMRI methods

"Metrology is the scientific domain in which imaging biomarkers must be validated, as with other measurement devices"
European Society of Radiology Statement on the Validation of Imaging Biomarkers, Insights into Imaging, 2020.
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